バリデートされた分析方法のリスト

バリデートされた測定法のリスト

当社は、数百に及ぶ特許化合物に対する測定法の開発及びバリデーションを行うことで、多くの製薬会社とパートナーシップを築いてまいりました。現在当社では、一連のバリデートされた測定法を構築しておりますので、御社の要望に沿った測定法のリクエストをお知らせください。

現在有効なバリデートされた非特許化合物の測定法は以下の通りです

List of Validated Assays
ALL A-F G-L M-R S-Z  
COMPOUND MATRIX CALIBRATION RANGE Anti-Coag LTMS TEMP
Acamprosate Human Plasma 0.500 to 200 ng/mL -
AFMU Human Urine 100 – 20,000 ng/mL None 244 -20
Aliskiren Human Plasma 1.00 – 500 ng/mL K2EDTA 204 -20
Amlodipine Human Plasma 0.500 – 100 ng/mL EDTA 47 -20
Amprenavir Human Plasma 10.0 – 10,000 ng/mL K3EDTA 72 -20
Aprepitant Human Plasma 10.0 – 5,000 ng/mL K3EDTA 214 -20
Armodafinil Human Plasma 100 – 10,000 ng/mL K3EDTA 102 -20
Atazanavir(NJ) Human Plasma 5.0 - 2,500 ng/mL K2EDTA 49 -20,-70
Atazanavir / Ritonavir Human Plasma 1.00 – 1,000 ng/mL EDTA -20
Atazanavir / Ritonavir Human Plasma 10.0 – 5,000 ng/mL K3EDTA 446 -20
Atorvastatin/ o-Hydroxy / p-Hydroxy Human Plasma 0.300 - 50.0 ng/mL K2EDTA 220 -20
Atorvastatin/ o-Hydroxy / p-Hydroxy Human Plasma 0.300 - 50.0 ng/mL K2EDTA 224 -70
Atorvastatin / Lactone / o-Hydroxy / p-Hydroxy Human Plasma 0.100 – 100 ng/mL K2EDTA 224 -70
Budesonide Human Plasma 10.0 to 5,000 pg/mL K2EDTA 123 -20
Buproprion/ Hydroxybuproprion/
Ethrohydroxybupropion / Threohydroxybuproprion		 Human Plasma 1.00 – 1,000 ng/mL K2EDTA 223 -70
Caffeine Human Plasma 10.0 - 10,000 ng/mL K2EDTA 223 -20
Capcitebine / 5'-Deoxy-5-fluorocytidine / 5'-Deoxy-5-fluorouidine Human Plasma 10.0 – 5,000 ng/mL Na2 EDTA 240 -20
Carboplatin Human Plasma
Ultrafiltrate		 50.0 – 40,000 ng/mL K2EDTA 262 -70
Carvedilol(NJ) Human Plasma 0.200 – 200 ng/mL EDTA 560 -70
Cinacalcet Human Plasma 0.100 – 50.00 ng/mL K3EDTA 252 -20
Ciprofloxacin / Levofloxacin / Moxifloxacin Human Plasma 10.0 – 1,000 ng/mL
Cyclobenzaprine Human Plasma 0.100 – 50.0 ng/mL K2EDTA 121 -20
Cytarabine/Ara-U Human Plasma 200 – 50,000 ng/mL K2EDTA 258 -20
Darifenacin Human Plasma 50.0 – 10,000 pg/mL K2EDTA 119 -20
Daunorubicin Human Plasma 0.100 – 10.0 ng/mL EDTA 200 -70
Daunorubicin/Daunorubicinol Rat Plasma 10.0 – 1,000 ng/mL EDTA 211 -70
Daunorubicin/Daunorubicinol Dog Plasma 10.0 – 1,000 ng/mL EDTA 211 -70
Dexlansoprazole Human Plasma 2.00 – 2,000 ng/mL K2EDTA 104 -20
Dexlansoprazole Human Plasma 2.00 – 2,000 ng/mL K2EDTA 84 -70
Dextromethorphan/Dextrorphan Human Plasma 0.500 - 250 ng/mL K2EDTA 273 -20
Dextromethorphan/Dextrorphan Human Urine 1.00 – 500 ng/mL K2EDTA 89 -20
Diclofenac Human Plasma 0.100 – 100 ng/mL NaHep 64 -20
Diclofenac Human Plasma 10.00 – 2,000 ng/mL K2EDTA 84 -20
Digoxin Human Plasma 0.100 to 50.0 ng/mL K2EDTA 177 -20
Docetaxel Human Plasma 5.00 – 5,000 ng/mL K2EDTA 80 -20
Donepezil Human Plasma 0.100 – 100 ng/mL K3EDTA 206 -20
Doxorubicin/Doxorubicinol Human Plasma 1.00 – 1,000 ng/mL EDTA 211 -70
Duloxetine Human Plasma 0.200 – 100 ng/mL K3EDTA 184 -20
Efavirenz Human Plasma 10.0 – 10,000 ng/mL K2EDTA 260 -20
Emtracitabine Human Plasma 5.00 – 5,000 ng/mL K2EDTA 330 -20
Entecavir Human Plasma 50.0 – 20,000 pg/mL K2EDTA 42,49 -20,-70
Erlotinib (Tarceva) and Metabolite Human Plasma 10.0 – 4,000 ng/mL K2EDTA 315 -70
Eszopiclone Human Plasma 1.00 – 100 ng/mL K3EDTA 235 -20
Famotidine Human Plasma 1.00 – 500 ng/mL K3EDTA 298 -20
Fentanyl Human Plasma 0.0500 - 50.0 ng/mL K2EDTA Pending -20,-70
Fluconazole Human Plasma 100 – 10,000 ng/mL K3EDTA 133 -20
5-Fluorouracil Human Plasma 1.00 – 500 ng/mL EDTA 1095 -20
Fluticasone propionate / Salmeterol Human Plasma 1.00 – 200 pg/mL K2EDTA/K3EDTA 91 -20
Formoterol Human Plasma 1.00 – 100 pg/mL K3EDTA 89 -20
Guanfacine Human Plasma 50.0 - 5000 pg/mL
Hydromorphone Human Plasma 25.0 – 5,000 pg/mL EDTA 87 -20
Hydromorphone / Hydrocodone / Norhydrocodone Human Plasma 0.100 – 50.0 ng/mL K2EDTA 87 -20
Ibandronate Human Plasma 0.100 – 50.00 ng/mL K2EDTA 170 -20
Ketoconazole Human Plasma 50.0 – 5,000 ng/mL K2EDTA 560 -20
Lenalidomide Human Plasma 1.00 – 1,000 ng/mL K2EDTA 376 -20
Lopinavir / Ritonavir Human Plasma 5.00 – 5,000 ng/mL K3EDTA 526 -20
Maraviroc Human Plasma 1.00 - 1,000 ng/mL K2EDTA 180 -20
Mefenamic acid Human Plasma 50.0 – 5,000 ng/mL K3EDTA 119 -70
Memantine Human Plasma 0.100 – 100 ng/mL K3EDTA 429 -20
Mesalamine Human Plasma 2.00 to 1000 ng/mL
R,S-Methadone Human Plasma 5.00 – 1,000 ng/mL K3EDTA 240 -20
Methotrexate / 7-Hydroxymethotrexate Human Plasma 1.00 – 500 ng/mL NaEDTA 527 -20
Methotrexate / 7-Hydroxymethotrexate Human Plasma 1.00 – 500 ng/mL K2EDTA 59 -20
Methotrexate / 7-Hydroxymethotrexate Human Plasma 1.00 – 500 ng/mL K2EDTA 50 -70
Methotrexate / 7-Hydroxymethotrexate Human Urine 1,000 - 50,000 ng/mL
50.0 - 2,500 ng/mL 		None 89 -20
1-Methyluric acid Human Urine 2,500 - 20,000 ng/mL None 131 -20
1-Methyluric acid Human Urine 2,500 - 20,000 ng/mL None 131 -70
1-Methylxanthine / 1,7-Dimethyluric acid Human Urine 500 - 20,000 ng/mL None 21 -20
1-Methylxanthine / 1,7-Dimethyluric acid Human Urine 500 - 50,000 ng/mL None 21 -20
Metoprolol Human Plasma 0.500 - 250 ng/mL Heparin/EDTA 121 -20,-70
Midazolam / 1-Hydroxymidazolam Human Plasma 0.100 - 10.0 ng/mL K2EDTA 1093 -20
Midazolam / 1-Hydroxymidazolam /
4-Hydroxymidazolam		 Human Plasma 0.100 - 50.0 ng/mL K2EDTA 117 -20
Moexipril / Hydrochlorothiazide Human Plasma 1.00 - 200 ng/mL K2EDTA 36 -70
Morphine / Morphine-6-glucuronide Human Plasma 0.500 - 100 ng/mL K2EDTA 462 -20
Morphine / Morphine-3-glucuronide / Morphine-6-glucuronide Human Plasma 0.500 - 50.0 ng/mL
10.0 - 1,000 ng/mL
1.00 - 100 ng/mL
Moxifloxacin Human Plasma 25.00 - 5,000 ng/mL K2EDTA 94 -20
Moxifloxacin Human Plasma 25.00 - 5,000 ng/mL NaHep 175 -20
Naltrexone / Naltrexol Human Plasma 20.0 - 2,000 pg/mL
0.500 - 50.0 ng/mL 		K2EDTA 174 -70
Naltrexone / Naltrexol Human Plasma 4.00 - 4,000 pg/mL
0.250 - 250.0 pg/mL 		K2EDTA 35 -20
Nelfinavir Human Plasma 1.00 - 1,000 ng/mL K3EDTA 100 -20
Nicotine/Cotinine Human Plasma 1.00 - 500 ng/mL
2.00 - 1,000 ng/mL		 EDTA 184,~481 -20,-70
Nifedipine Human Plasma 1.00 - 250 ng/mL K2EDTA 277 -20
Nilotinib Human Plasma 5.00 - 2,000 ng/mL K2EDTA 102 -20
Nisoldipine Human Plasma 50.0 - 10,000 pg/mL K2EDTA 288 -20
Olanzapine Human Plasma 0.400 - 100 nM K2EDTA 234 -20
Omeprazole / 5-Hydroxyomeprazole Human Plasma 10.0 - 1,000 ng/mL K3EDTA 141 -20
Oxycodone Human Plasma 0.200 – 100 ng/mL EDTA 97 -20
Oxymorphone Human Plasma 0.0500 – 25.0 ng/mL EDTA 97 -20
Paclitaxel Human Plasma 10.0 - 2,000 ng/mL K3EDTA 433 -20
Paclitaxel Human Plasma 10.0 - 5,000 ng/mL K2EDTA 164 -20,-70
Paliperidone (9-Hydroxy Risperidone) Human Plasma 0.100 – 100 nM
Pramipexole Human Plasma 50.0 - 5,000 pg/mL K3EDTA 35 -20
Pregabalin Human Plasma 50.0 - 20,000 ng/mL K2EDTA 538 -20
Quetiapine Human Plasma 0.500 - 2,000 ng/mL K2EDTA 194,3 -20,-70
Raltegravir Human Plasma 1.00 - 1,000 ng/mL
Ramelteon Human Plasma 50.0 - 8,000 pg/mL K2EDTA 95 -20
Ranolazine Human Plasma 5.00 - 5,000 ng/mL K2EDTA Pending -20,-70
Rifaximin Human Plasma 0.100 - 10.0 ng/mL K2EDTA 448 -20
Riluzole Human Plasma 500 - 2,000 ng/mL K3EDTA -20
Risperidone / 9-Hydroxy Risperidone (Paliperidone) Human Plasma 0.400 - 100 nM K2EDTA 219 -20
Sertraline Human Plasma 10.0 - 5,000 ng/mL
Simvastatin/Simvastatin hydroxy acid Human Plasma 0.100 - 50.0 ng/mL
Sitagliptin Human Plasma 1.00 - 1,000 ng/mL EDTA 132 -70
Tadalafil Human Plasma 1.00 - 500 ng/mL K3EDTA 137 -20
Temozolomide Human Plasma 100 - 20,000 ng/mL K2EDTA 273 -20
Tenofovir Human Plasma 5.00 - 5,000 ng/mL K2EDTA 346 -20
Tenofovir Human Plasma 5.00 - 5,000 ng/mL K2EDTA 239 -70
Tetracyclines Human Urine 0.200-10 mcg/mL
Tetracycline / Oxytetracycline / Demeclocycline / Doxycycline Human Urine 200 - 50,000 ng/mL Human Urine 48 -70
Theophylline Human Plasma 100 - 50,000 ng/mL K2EDTA 89 -20
Tramadol Human Plasma 5.00 - 500 ng/mL K2EDTA 309 -20
Trazadone Human Plasma 10.0 - 5,000 ng/mL K2EDTA 182 -20
Uracil Human Plasma 20.0 - 10,000 ng/mL
R-Warfarin/ S-Warfarin Human Plasma 10.0 - 1,000 ng/mL K3EDTA 988 -20
Valsartan Human Plasma EDTA 50.0 - 10,000 ng/mL K3EDTA 621 -20
Vancomycin Human Plasma 50.0 - 10,000 ng/mL K2EDTA 63 -20,-70
Vardenafil Human Plasma 0.200 - 50.0 ng/mL K2EDTA 623 -20
Velcade Human Plasma 0.100 - 25.00 ng/mL K2EDTA 611 -70
Voriconazole Human Plasma 5.00 - 5,000 ng/mL K3EDTA 623 -20