Tandem Labs

"Increase Drug Tolerance of Immunogenicity Assay by Affinity Purification with a Novel Technical Platform," by Xiguang Li, Edward Brewer, and KC Van Horne; Presented at CHI's Third Annual Immunogenicity Summit 2011 in Bethesda, MD, November 16-18, 2011. Click Here

"Development and Validation of an LC/MS/MS Method for Detection and Quantification of AD-TTR, the siRNA Component of ALN-TTR02 in Rat and Monkey Plasma," by Hongliang Cai, Garvin Warner, Akshay Vaishnaw, and Renta Hutabarat from Alnylam Pharmaceuticals, as well as Laixin Wang from Tandem Labs; Presented at AAPS Annual Meeting and Exhibition in Washington, DC, October 23-27, 2011.

"A Rugged and Sensitive Method for the Determination of Albuterol in Human Plasma by LC/MS/MS," by Brad Bessette, Min Meng, and Spencer Carter; Presented at AAPS Annual Meeting and Exhibition in Washington, DC, October 23-27, 2011. Click Here

"Sensitive and High-Throughput Analysis of Octreotide in Human Plasma Using LC/MS/MS," by Yao Shi, Laixin Wang, Bradley Bessette, Spencer Carter, and Scott Reuschel; Presented at AAPS Annual Meeting and Exhibition in Washington, DC, October 23-27, 2011. Click Here

"Simultaneous Quantitation of Polymyxin PMB1-1 and PMB2 in Human Urine Using LC/MS/MS," by Weiwei Yuan, Laixin Wang, Yao Shi, Toni Pollock, Scott Reuschel, Min Meng, Lynn Chevrette, and Lihong Gao; Presented at AAPS Annual Meeting and Exhibition in Washington, DC, October 23-27, 2011. Click Here

"Quantitative Determination of Etoposide in Human Plasma Using LC/MS/MS," by Yifei Liu, Daria Wentzel, Roger Demers, Laura Cojocaru, Erika Hess, and Laura Potenza; Presented at AAPS Annual Meeting and Exhibition in Washington, DC, October 23-27, 2011. Click Here

"LC/MS Detection and Quantitation of a Small Anion, Thiocyanate, by Ion-Pair Chromatography,"by Roger Demers, Daria Wenzel, and Laura Cojocaru. #461; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Novel Assay with Phospholipids Column Trapping and Switching Valve System for the Determination of Carboplatin in Human Plasma by LC/MS/MS,"by Yifei Liu, Roger Demers, Daria Wentzel, Erika Hess, and Laura Cojocaru. #528; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Impact of Hemolysis on the Quantitation of LC/MS/MS Assays: Case Studies of Mesalamine, Albuterol, and Asenapine in Human Plasma,"by Spencer Carter, Wei Wei Yuan, Yue Zhao, Brad Bessette, and Min Meng. #678; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"A Systemic Approach to Address and Resolve Issues Involved in Peptide Quantitation,"by David Ho, Kojo Abdul-Hadi, and Lily Li as well as Randal Eckert from C3 Jian Inc., Inglewood, CA. #724; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"An Ultra Sensitive Method for the Determination of Albuterol in Human Plasma by LC/MS/MS,"by Brad Bessette, Min Meng, Yifei Liu, Laura Cojocaru, and Spencer Carter. #789; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Converting Plasma Assays to DBS Assays: Challenges and Comparison of Two Riluzole Assays in Different Matrices,"by Min Meng. #959; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Examining the Roles of Species, pH, and Ionization in Contributing to Divergence in a Series of Structurally Similar Small Molecules,"by Kristopher King, Kojo Abdul-Hadi, and Rosanna Nguyen-Hak. #1110; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Quantification of LTE4 in Human Urine with a 2 pg/mL LLOQ using UPLC and LC/MS/MS,"by Lin Tan and Troy Voelker of Tandem Labs, and Katherine Wright and Joe Palandra of Pfizer, Andover, MA. #1293; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Overcoming Challenges in Development of a Single Extraction LC/MS/MS Method for an Unstable Metabolic Compound Forming Two Chemically Different Metabolites,"by Ryan Adler, Yue Zhao, Laixin Wang, Min Meng, Troy Voelker, and Todd Chappell; #1354; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Sensitive and High-Throughput Bioanalysis of Octreotide using LC/MS/MS,"by Yao Shi, Laixin Wang, Brad Bessette, Spencer Carter, Scott Reuschel, and Min Meng. #1776; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Two Dimensional PPE/SPE Extraction Coupled with Three Dimensional HPLC/UPLC/MS/MS for a 500 fg/mL LLOQ Assay,"by Troy Voelker, Lin Tan, and Min Meng of Tandem Labs as well as Andrew Acheampong, John Ling, and Gabriella Szekely-Klepser of Allergan Pharmaceuticals, Irvine, CA. #2187; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Quantification of Tiotropium in Human Plasma with a 1 pg/mL LLOQ using HPLC and LC/MS/MS,"by Yue Zhao, Stephanie Harrison, Troy Voelker, and Min Meng. #2428; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Fast Quantitation of Biomarkers N-Acetylaspartate and N-Acetylaspartylglutamate in Mouse Brain Homogenates Using HILIC and Tandem Mass Spectrometry,"by Monica Germann and Kendall Powell. #2483. Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Quantitative LC/MS/MS Assay Development of Alzheimer's Disease Serum Protein Biomarkers Using a Library of Proteolytic MS Spectra,"by Bob Xiong, Kojo Abdul-Hadi, and Lily Li. #3118; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"UPLC/MS/MS Analysis of Bimatoprost and its Free Acid Metabolite from Mini-pig Skin,"by Lisa Ford and Mike Allen of Tandem Labs; Kevin Wilkinson of Enthalpy Analytical, Durham, NC; and Lisa Borbridge of Allergan Pharmaceuticals, Irvine, CA. #3274; Presented at ASMS 58th Conference in Denver June 5-9, 2011. Click Here

"Identifying Trends and Developing Solutions for Incurred Sample Reanalysis Failure Investigations in a Bioanalytical CRO," by Min Meng, Scott Reuschel, Patrick Bennett. Bioanalysis 3:4, 449-465, 2011.

"Bioanalysis of Oligonucleotide Therapeutics: LC-MS/MS Allows for Accurate and Sensitive HT Quantification," by Laixin Wang; Genetic Engineering and Biotechnology News,Jan 15 2011; 31(2): 26-27. Click Here

"Quantitative Determination of Riluzole: Plasma with Protein Precipitation Extraction vs. Whole Blood (Dried Blood Spots) with Liquid-Liquid Extraction," by Yifan Shi, Min Meng, Yue Zhao, Scott Reuschel, and KC Van Horn; Presented at the 2010 AAPS Annual Meeting and Exposition, New Orleans, LA, November 2010. Click Here

"The Determination of a Tetra-Phosphate Compound in Rat Plasma by LC/MS/MS," by Denny Yifel Liu and Laura Cojocaru; Presented at the 2010 AAPS Annual Meeting and Exposition, New Orleans, LA, November 2010. Click Here

"A Validated Method for Quantitative Vancomycin in Human Plasma Using On-Line SPE-LC/MS/MS," by Laura Cojocaru, Roger Demers, Denny Yifei Liu, and Erika Hess; Presented at the 2010 AAPS Annual Meeting and Exposition, New Orleans, LA, November 2010. Click Here

"Quantification of Lipids and the Challenge of Developing LC/MS Methods for Compounds with both Hydrophilic and Hydrophobic Characteristics," by Lin Tan, Troy Voelker, Yue Zhao, Ryan S. Adler, Cassie Ye, Min Meng, Patrick Bennett, and Scott Reuschel; Presented at the 2010 AAPS Annual Meeting and Exposition, New Orleans, LA, November 2010; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Quantitative Determination of a Phosphothioate Oligonucleotide in Dog Plasma Using LC/MS/MS," by Yue Zhao, Laixin Wang, Weiwei Yuan, Ryan Adler, Min Meng, and Scott Reuschel; Presented at the 2010 AAPS Annual Meeting and Exposition, New Orleans, LA, November 2010; Presented at the TIDES: Oligonucleotide and Peptide Technology and Product Development, Boston, MA, April 2010. Click Here

"Evaluation of Analyte Stability on Dried Blood Spot Cards," by Suraj Dhungana, Michael Allen, David Minser, Robert Friley, and D. Craig Skyes; Presented at the APA / BSAT, Baltimore, MD, Setember 2010. Click Here

"Ultra-High Throughput ADME Screening Using LDTD Methodology ," by Ming-Chih D. Ho and Lily Li, Tandem Labs and Ming-Xiang Liao, Qing Zhu, and Cindy Xia, Millennium Pharmaceuticals; Presented at the APA / BSAT, Baltimore, MD, Setember 2010. Click Here

"Quantitation of a Phosphothioate Oligonucleotide in Rat Plasma Using LC/MS/MS," by Weiwei Yuan, Laixin Wang, Yue Zhao, Gregory vonArx, Yao Shi, Scott Reuschel, and Min Meng; Presented at the 2010 AAPS National Biotechnology Conference (AAPS-NBC), San Francisco, CA, June 2010. Click Here

"Investigation of Lot-to-Lot Matrix Variation and Carry-over for a Small Peptide in Human Serum," by Yifei Liu and Jessica Schofield; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Single Analyte Mediated Quantitative Determination of Endogenous 5-HETE and 5-OXO-ETE in Plasma Samples," by Ling Morgan, Kris King, Guangyu Zhao and Chris Tran; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Identifying Trends and Improving Outcomes from Incurred Sample Analysis Failure Investigations in a Bioanalytical CRO," by Patrick Bennett, Min Meng, and Scott Reuschel (Oral Presentation); Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Evaluation of Drug Plasma Stability Using an Ultra-High Throughput Laser Diode Thermal Desorption (LDTD) Methodology," by Ming-Chih D. Ho and Lily Li of Tandem Labs as well as Ming-Xiang Liao and Cindy Xia from Millennium Pharmaceuticals, Inc., Cambridge, MA; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"When Stability, Solubility, and Chiral Selectivity Intertwine: A Quantitative Assay for Dexlansoprazole," by Ryan S. Adler, Brad Bessette, Min Meng, Spencer Carter, Scott A. Reuschel, and Patrick Bennett; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Determination of Lipoxygenase Products of Arachidonic Acid in Tissue and Plasma by LC-MS/MS" by Ling Morgan, Kristopher W. King, Guangyu Zhao, and Chris Tran; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Practice of Protein Biomarker Assay Development and Validation from Drug Discovery to Development," by Lily Li, Bob Xiong, Ming-Chih D. Ho, and Patrick Bennett; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Determination of Entecavir in Human Plasma using LC/MS-MS," by Yifei Liu and Erika Hess; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Determination of Vancomycin in Human Plasma using LC/MS-MS," Yifei Liu and Erika Hess; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Investigation of Extraction Recovery for a Novel Anti-cancer Agent in Rat and Beagle Whole Blood," by Yifei Liu and Carl Bates of Tandem Labs, as well as Martin Paton; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Femtogram Quantitation of Naltrexone and 6-B-Naltrexone in Human Plasma by LC-MS/MS" by Roger Demers and Angela Lynn McGrath; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Quantitation of Tetracycline and 3 Derivatives in Human Urine by LC-MS/MS" by Roger Demers, Daria Wentzel, Yifei Liu, Laura Cojocaru, Erika Hess, and Heike Mongiovi; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"A Fully Automated Online Extraction Method for Determination of Raltegravir in Plasma by LC/MS/MS," by Yifan Shi, Min Meng, Lisa Rohde, Troy Voelker, Lin Tan, Scott Reuschel, Patrick Bennett, and KC Van Horne; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Quantification of a Very Polar Small Molecule, Guanfacine, in Human Plasma using an Acquity UPLC and a 50 pg/mL LLOQ," by Troy Voelker, Lin Tan, Min Meng, Spencer Carter, and Scott Reuschel; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Quantification of Caffeine Metabolites in Human Urine via a Simple and Rapid Liquid Chromatography-Tandem Mass Spectrometry Method," by Yao Shi, Laixin Wang, Jian Chen, Lisa Rohde, Spencer Carter, Min Meng, Scott Reuschel, and Patrick Bennett; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Laser Diode Thermal Desorption (LDTD)-MS/MS Analysis of Chloroquine, Proguanil and Mefloquine in Human Urine," by Sherry Liu, Scott Reuschel, Min Meng, and Patrick Bennett of Tandem Labs as well as Serge Auger, Pierre Picard, and Patrice Tremblay from Phytronix Technologies, Inc., Quebec, QC; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Comparison of Liquid/Liquid and Solid-Phase Extraction for the Quantitative Analysis of Phosphorothioate Oligonucleotides in Human Plasma Using LC-MS/MS," by Weiwei Yuan, Laixin Wang, Yue Zhao, Yao Shi, Min Meng, Scott Reuschel, and Patrick Bennett; Presented at the ASMS 58th Conference on Mass Spectrometry, Salt Lake City, UT, May 2010. Click Here

"Obtaining Sensitive Lower Limits of Quantitation for the Determination of Fluticasone Propionate, Salmeterol, Formoterol, and Budesonide in Human Plasma by LC/MS/MS,"by Spencer Carter and Min Meng; Presented at the Respiratory Drug Delivery (RDD), Orlando, FL, April 2010. Click Here

"Evaluation of in vitro models for REACH toxicity testing: Inducibility of xenobiotic metabolizing enzyme (XME) activity in in vitro human airway (EpiAirway) and epidermal (EpiDerm) models," by Jennifer Bolmarcich, George R. Jackson, Mitchell Klausner, and Patrick J. Hayden from MatTek Corporation, Ashland, MA and Guangyu Zhao, Ling Morgan, and Thomas Falzareno from Tandem Labs, Woburn, MA; Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT , March 2010.

"Quantitation of TL0901 Oligonucleotide in Human Plasma Using LC/MS/MS," by Laixin Wang, et al; Presented at the 2009 AAPS Annual Meeting and Exposition, Los Angeles, CA, November 2009. Click Here

"Software Assisted Chiral Chromatographic Method Development for the Quantitation of Four Chiral Drugs in Monkey Plasma using LC/MS/MS," Troy Voelker, et al; Presented at the 16th North American Regional Meeting for the International Society for the Study of Xenobiotics (ISSX), Baltimore, Maryland, October 2009. Click Here

"Analysis of Highly Hydrophilic Compounds in Biological Matrices with LC/MS/MS Normal Phase LLE for Sample Preparation," Kristopher W. King, Chris Tran, Guangyu Zhao, Ling Morgan; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Novel Approaches to Developing LC/MS/MS Bioanalytical Methods for Liposomal Encapsulations," Roger Demers, A. Lynn McGrath, Scott Klepfer, Daria L. Wentzel; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"What is a Better Approach to Quantifying Endogenous Molecules: Using Labeled Compound, Surrogate Matrix, or Non-Labeled Compound?," Bob Xiong, Kojo Abdul-Hadi, Patrick Bennett, Lily Li; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"The Combined Quantitation of Two Challenging Compounds, Fluticasone and Salmeterol, on a New Tandem Mass Spectrometer," Edward Brewer, Min Meng, Patrick Bennett, Spencer Carter, Robert Horton, Gerard Dalglish as well as George Scott, Ionics Mass Spectrometry Group, Inc., Ontario, Canada; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Computer Software-Assisted Chiral Chromatographic Method Development for the Quantitation of Four Chiral Generic Drugs in Human Plasma Using LC/MS/MS," Patrick Bennett, Min Meng, Lisa Rohde; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"500 Discovery Samples a Day: Maximizing Throughput and Minimizing Matrix Effects in Discovery Analysis," Rob Horton, Gerard Dalglish, Edward Brewer; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Overcome Non-phospholipid Related Matrix Effect and Continuing Improvement for a LC/MS/MS Assay for the Quantification of Naltrexone and 6 B-Naltrexol in Human Plasma," Min Meng, Lin Tan, Troy Volker, Ryan Adler, Spencer Carter, Patrick Bennett, David Anderson; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"What Do We Learn about Hepatotoxicity Using Coumarin-Treated Rat Model?," M. David Ho, Bob Xiong, Patrick Bennett, Lily Li, as well as S. Stellar, J. Proctor, J. Silva, and H.K. Lim, Johnson & Johnson PRD, Raritan, NJ; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Method Development and Validation for the Quantitation of Bupropion and its Metabolites in Human Plasma Using UPLC/MS/MS," Lin Tan, Troy Voelker, Min Meng, Patrick Bennett; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Method Development Strategies for Improving ISR Reproducibility Use of Surfactants for Success," Daria L. Wentzel, Roger Demers; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Hepatoxicity Biomarkers Found from Coumarin-Treated Rat Liver Tissues Utilizing MALDI TOF and FTMS Imaging Techniques," Lily Li, David Ho, Bob Xiong, Patrick Bennett, as well as Kathy Kellersberger, Paul Kowalski, Jane-Marie Kowalski, Paul Speir from Bruker Daltonics, Billerica, MA and S. Stellar, J. Proctor, J. Silva, and H.K. Lim from Johnson & Johnson PRD, Raritan, NJ; Presented at the 2009 ASMS Conference, Philadelphia, PA, June 2009. Click Here

"Investigation of Interaction Between Salmeterol and Fluticasone propionate and its Effect on Quantitative Accuracy of an LC/MS/MS Assay in Human Plasma at Low pg/mL Concentrations," Spencer Carter, et al. Journal of Chromatography B, November 2008. 876:163 - 169. Click Here to Order a Reprint

"Quantitative determination of AS1411 oligonucleotide in human urine using UPLC-PDA," Yanhui Zhang, Laixin Wang, Jian Chen, Yue Zhao, Min Meng and Patrick Bennett (Tandem Labs) as well as Donna Dobinson and Colin Green (Antisoma Research Limited, Welwyn Garden City, UK); Presented at the 11th Annual Symposium on Chemical & Pharmaceutical Structure Analysis, Langhorne, PA, October 2008. Click Here

"Quality Throughput in the Bioanalytical Lab," Luca Matassa; Presented at the 11th Annual Symposium on Chemical & Pharmaceutical Structure Analysis, Langhorne, PA, October 2008. Click Here

"Quantitative determination of AS1411 oligonucleotide in monkey plasma using UPLC-PDA," Jian Chen, Laixin Wang, Yanhui Zhang, Ming Meng, Juan Wang and Patrick Bennett (Tandem Labs) as well as Donna Dobinson and Colin Green (Antisoma Research Limited, Welwyn Garden City, UK); Presented at the ISSX 15th Annual Meeting, San Diego, CA, October 2008. Click Here

"Identification of new dexamethasone derivatives in rabbit plasma samples ," David Ho, Lisa Rohde, Min Meng, Patrick Bennett and Lily Li (Tandem Labs) as well as Begona Ruiz-Perez and Mike Patane (EyeGate Pharma); Presented at the ISSX 15th Annual Meeting, San Diego, CA, October 2008. Click Here

"Chromatographic improvements and overcoming matrix effects and carryover for a previously validated nine analyte LC/MS/MS assay using UPLC," Edmonda Cook, Min Meng and Patrick Bennett; Presented at the 2008 Bioanalytical, 9th Annual Land O'Lakes Conference, Merrimac, WI, July 2008. Click Here

"Immunogenicity assays using a novel ELISA format: comparison of sensitivity and drug tolerance to electrochemiluminescence (meso-scale discovery)," Robert J. Kubiak, et al; Presented at the 2008 AAPS National Biotechnology Conference, Toronto, Canada, June 2008. Click Here

"Overcoming challenges in development of LC/MS/MS methods for highly polar, low molecular weight, zwitterionic compounds: a quantitative assay for pregabalin," Ryan S. Adler, Spencer J. Carter, Troy Voelker; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Chiral chromatographic method development and validation for the quantitation of eszopiclone in human plasma using LC/MS/MS," Min Meng, Lisa Rohde, and Patrick Bennett, as well as Vladimr 到pka, Astra Zeneca Pharmaceuticals LP; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Case studies of accurate measurement of small molecule drugs in various tissues: knowledge versus assumption," Marcele L. Barroso, Kristopher W. King, Chris Tran, Angela Shen and Xin Zhang; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Is MALDI-TOF MS ready for bioanalytical analysis?," Patrick Bennett, Qing Zhu, KC Van Horne, and Lily Li, as well as Yulin Huang, Vertex Pharmaceuticals; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Simultaneous quantitation of cytarabine and uracil arabinofuranoside in human plasma using LC-MS/MS," Laixin Wang, Yanhui Zhang, Roger Demers, Min Meng and Patrick Bennett; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Methodology of accelerating bioanalysis method development in drug discovery with LC/MS/MS," Ling Morgan, Guangyu Zhao, Xin Zhang, Lily Li; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Method development of LC-MS/MS analysis of aminoglycoside drugs: challenges and solutions," Angela (Qi) Shen, Ling Morgan, Marcele L. Barroso and Xin Zhang, as well as Tuyen Nguyen, Sepracor Inc.; Presented at the 2008 ASMS Conference, Denver, CO, June 2008. Click Here

"Non-ionization related matrix effects on quantitative determination of EC78 and its metabolites in human plasma using LC/MS/MS," Laixin Wang, Ming Meng, Brittney Weber, Troy Voelker, Jim Johnston, Luca Matassa, and Patrick K. Bennett from Tandem Labs as well as Samina Khan, Ron Huang, and Liyu Yang from Biogen Idec, San Diego, CA; Presented at the 2007 AAPS Annual Meeting, San Diego, CA, November 2007. Click Here

"Quantitation of Endogenous Plasma Thymidine Using ¹³C Labeled Thymidine as Surrogate Analyte," Min Meng and Patrick K. Bennett, et al, as well as Genentech, Inc. (South San Francisco, CA); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007; Presented at the 2007 AAPS Annual Meeting, San Diego, CA, November 2007. Click Here

"Dealing with Assay Performance Problems (Investigation, Corrective Action and Preventive Action)," Luca Matassa; Speaking engagement at the 2007 BSAT/APA conference, Boston, MA, September 17, 2007. Presentation

"Challenges of Modifying an Existing Quantitative Assay: Adding a New Metabolite," Patrick K. Bennett, Ryan Adler, et al, as well as Pfizer, Inc., PGRD Groton Laboratories (Groton, CT); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007; Presented at the 2007 Bioanalytical, 8th Annual Land O'Lakes Conference, Merrimac, WI, July 2007. Click Here

"Minimizing matrix effects in the development of a method for the determination of salmeterol in human plasma by LC/MS/MS at low pg/mL concentration levels," Vladimír Čápka,, Spencer J. Carter; Journal of Chromatography B June 2007; 856: 285293.

"Focus on Method Selectivity: A Means to Reduce Matrix Effects and Increase Throughput and Ruggedness in Bioanalytical LC/MS/MS Applications," Vladimír Čápka, et al; Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

"Quantitative Determination of Phlorizin in Human Plasma and Urine Using LC/MS/MS," Robert Marquardt, et al, as well as the Department of Medicine, University of Colorado (Aurora, CO); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

"Urea Increases Extraction Recovery and Assay Specificity for Drug Analysis in Human Breast Milk Using LC/MS/MS," Laixin Wang, et al, as well as Immtech Pharmaceuticals, Inc. (Vernon Hills, IL); Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

"An Orthogonal Approach to Increasing Assay Ruggedness at Low Limits of Quantitation in LC/MS/MS Assays," Spencer Carter, Vladimír Čápka, and Stephen Viccarone; Presented at the 2007 ASMS Conference, Indianapolis, IN, June 2007. Click Here

"Determination of Warfarin Enantiomers in Human Plasma Using LC/MS/MS in the Presence of Twelve Co-administered Drugs and Metabolites," Vladimír Čápka, Spencer J. Carter, and Stephen Viccarone; Presented at the AAPS Annual Meeting, San Antonio, TX, October 2006. Click Here

"Strategy for Conducting Equilibrium Dialysis of Plasma Samples and Subsequent LC-MS/MS Analysis of the Resultant Samples," Xiaohui (Sophia) Xu, Anne Rose, Timothy Eley, Mohammed Jemal, Stanley Howell, Timothy Olah, and Mark Arnold from Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, New Jersey; and John Ryan, Roger Demers, and Ed Brewer from Tandem Labs; Presented at the AAPS Annual Meeting, San Antonio, TX, October 2006. Click Here

"Variable Between and Within Species Ionization Matrix Effects Using Negative Ion ESI-LC/MS/MS," Patrick K. Bennett, Laixin Wang, Min Meng, and Brad Johnston; Presented at the ISSX 14th Annual Meeting, Rio Grande, Puerto Rico, October 2006. Click Here

"Evaluation of Alternative HT Intrinsic Clearance Measurement in Rat Liver Microsomes," M. David Ho, Yulin Huang, and Lily Li; Presented at the 9th Annual Symposium on Chemical & Pharmaceutical Structure Analysis (CPSA), Princeton, NJ, October 2006. Click Here

"Managing phospholipid-based matrix effects In bioanalysis," Patrick K. Bennett, Min Meng, and Vladimír Čápka,; Presented at the 17th International Mass Spectrometry Conference, Prague, Czech Republic, August 2006. Click Here

"Quantitative determination of endogenous glucose in human nerve tissues and erythrocytes by turboionspray LC/MS/MS," Laixin Wang, Min Meng, KC Van Horne, and Patrick K. Bennett; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Using supercritical fluid chromatography MS to alleviate the imprecision in bioanalysis resulting from the matrix effect of phospholipids," Patrick K. Bennett and Edward Brewer, as well as Mettler Toledo AutoChem (Newark, DE); Presented at the 2006 ASMS Conference, Seattle, WA, May 2006.

"A novel approach to quantify unbound cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate by measuring platinum-DDTC complex using LC/MS/MS," Min Meng, Ryan Kuntz, Al Fontanet, and Patrick K. Bennett; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Non-intuitive strategies for minimizing matrix effects in development of ultrasensitive bioanalytical LC/MS/MS methods," Vladimír Čápka, and Spencer J. Carter; Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Overcoming the interaction between fluticasone propionate and salmeterol in a combined validated assay by LC/MS/MS," Spencer J. Carter, Vladimír Čápka, Edward Brewer, and Patrick K. Bennett. Presented at the 2006 ASMS Conference, Seattle, WA, May 2006. Click Here

"Implication of phospholipids in significant matrix effects in negative ion ES-MS/MS," Tianyi Zhang, Min Meng, KC Van Horne, and Patrick K. Bennett; Presented at the 2005 AAPS Annual Meeting and Exposition, Nashville, TN, November 2005. Click Here

"Quantitative determination of endogenous sorbitol and fructose in human erythrocytes by atmospheric-pressure chemical ionization LC tandem mass spectrometry," H.R. Liang, T. Takagaki, R.L. Foltz, P. Bennett; Journal of Chromatography B, September 2005; 824(1-2):36-44. Click Here

"Quantitative determination of endogenous sorbitol and fructose in human nerve tissues by atmospheric-pressure chemical ionization liquid chromatography/tandem mass spectrometry," H.R. Liang, T. Takagaki, R.L. Foltz, P. Bennett; Rapid Communications in Mass Spectrometry, August 2005; 19(16):2284-2294. Click Here

"Elimination of endogenous interferences in analysis of polar compounds in biological fluids by HILIC and RP-HPLC in LC/MS/MS bioanalytical applications," Vladimír Čápka,, Patrick K. Bennett; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Identification of plasma components resulting in significant matrix effects in negative ion ESI-MS/MS," Patrick Bennett, Min Meng, KC Van Horne; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Quantitative API LC/MS/MS bioanalysis and matrix effects: considerations when changing source types," Luca C. Matassa, KC Van Horne, Christopher R. Bowerbank, Mark Anthony Reviea, Teresa Collazo, Shaundel Percey, Patrick K. Bennett; Presented at the 2005 ASMS Conference, San Antonio, TX, May 2005. Click Here

"Quantitative determination of dipyridamole in human plasma using liquid chromatography and electrospray ionization tandem mass spectrometry," Jerry Brisson, Christopher R. Bowerbank, Patrick K. Bennett. Tandem Labs and Otsuka Maryland Research Institute, Inc. Presented at the 2004 AAPS Annual Meeting and Exposition, Baltimore, Maryland, October 2004. Click Here

"Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry," H.R. Liang, R.L. Foltz, M. Meng, P. Bennett; Journal of Chromatography B, July 2004; 806(2):191-198. Click Here

"Overcoming matrix effects resulting from biological phospholipids through selective extractions in quantitative LC/MS/MS," Patrick Bennett, Hairui Liang; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"LC/MS/MS assay using traditional GC/MS derivitization to allow small polar compound analysis," Brad I. Coppersmith, Edward A. Brewer, Jean Pineault;, Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004.Click Here

"Sensitive and selective LC/MS/MS method for determination of endogenous polyols in human nerve tissues," Hairui Liang, Rodger L. Foltz, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Investigation of analyte recoveries from a new sorbent designed to remove phospholipids and reduce associated matrix effects," KC Van Horne, Min Meng, Robert Marquardt, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Source for imprecision resulting from ionization suppression from strongly retained phospholipids and dioctyl phthalate," Min Meng, Patrick Bennett; Presented at the 52nd ASMS Conference on Mass Spectrometry, Nashville, TN, May 2004. Click Here

"Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry," H. R. Liang, R. L. Foltz, M. Meng, P. Bennett; Rapid Communications in Mass Spectrometry, December 2003; 17(24):2815-2821. Click Here

"Identification of the major endogenous and persistent compounds in plasma, serum, and tissue that cause matrix effects with electrospray LC/MS techniques," Patrick Bennett, KC Van Horne; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Preventing matrix effects by using new sorbents to remove phospholipids from biological samples," KC Van Horne, Patrick Bennett; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Simple and rapid determination of carboplatin in human plasma ultrafiltrate using LC/MS/MS by direct injection coupled with post column addition," Min Meng, Sherry Liu, Patrick Bennett; Presented at the 2003 AAPS Annual Meeting and Exposition, Salt Lake City, Utah, October 2003. Click Here

"Ionization enhancement in APCI and suppression in ESI between target drugs and stable isotope-labeled internal standards in quantitative LC/MS and LC/MS/MS," Hairui Liang, Rodger L. Foltz, Min Meng, Pat Bennett; Presented at the ASMS Conference, Montreal, Canada, June 2003. Click Here

"Method development and validation for quantitative determination of methadone enantiomers in human plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," Hairui Liang, Min Meng, Pat Bennett, Rodger L. Foltz; Presented at the ASMS Conference, Montreal, Canada, June 2003. Click Here

"Development of a LC/MS assay for the quantification of levofloxacin and moxifloxacin in human plasma," Min Meng, Uma Robbie, Spencer Carter, Anna Akrami, Mari Heybroek, Xianrong Wei, Toni Peacock, Al Fontanet, Tonya Felix, Jerry H Brisson, Patrick Bennett; Tandem Labs and Otsuka Maryland Research Institute, Inc.; Presented at the 2002 AAPS Annual Meeting and Exposition, Toronto, Canada, November 2002.

"Overcoming imprecision resulting from water loss during the quantitation of moxifloxacin and levofloxacin in human plasma using atmospheric pressure ionization mass spectrometry," Spencer Carter, Min Meng, Mari Heybroek, and Patrick Bennett; Presented at the ASMS Conference, Orlando, FL, June 2002.

"Determination of NO-1886, an activator of lipoprotein lipase, and its metabolite in human plasma using SPE and LC/MS/MS," S.A. Reuschel, M. Meng, P. Bennett, T. Johnson, D. Mulford.; Tandem Labs and Tap Pharmaceutical Products, Inc. Presented at the 2001 AAPS Annual Meeting and Exposition, Denver, November 2001.

"Safety and clinical pharmacokinetics of DB289, a new orally bioavailable dication," P. Yeramian, M. Kruse, J. Allen, L. McChesney-Harris, K. Trendler, J. Hall, D.Boykin, R.Tidwell. Tandem Labs and Immtech International, Inc. Presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2001.

"Quantification of the prodrug DB289 and an active metabolite, DB75, in rat and monkey plasma using SPE, liquid chromatography and electrospray ionization tandem mass spectrometry," Kerri Trendler, James Allen, Ed Hall, Chad Stephens, Scott Reuschel, Gretchen Eagle, Patrick Bennett. Tandem Labs and Immtech International, Inc. Presented at the 2000 AAPS Annual Meeting and Exposition, Indianapolis, November 2000.

"Quantitative determination of a novel peptide, conantokin G, in biological matrices by liquid chromatography-tandem mass spectrometry," L. Jiang, R. Foltz, M. Morgan, R. McCabe. Tandem Labs and Cognetix, Inc. Presented at the 2000 AAPS Annual Meeting and Exposition, Indianapolis, October 2000. Click Here

"Rapid approach to resolve a matrix effect in a complex mixture of analytes," Patrick Bennett, Brad Coopersmith, Marc Browning, Jennifer Cragun, Edward Brewer, Jerry Brisson, Steven Bramer. Tandem Labs and Otsuka Maryland Research Institute, Inc. Presented at the ASMS Conference, Long Beach, CA, May 2000. Click Here

"Quantitative determination of a novel peptide, conantokin G, in rat plasma and serum by liquid chromatography-tandem mass spectrometry," L. Jiang, R. Foltz, M. Morgan, R. McCabe. Tandem Labs and Cognetix, Inc. Presented at the ASMS Conference, Long Beach, CA, May 2000.

"Determination of metformin in human plasma using liquid/liquid extraction and gas chromatography/mass spectrometry," S.A. Reuschel, M.E. Arnold, S. Percy, S. Liu, R.L. Foltz. Tandem Labs and Bristol-Myers Squibb. Presented at the 1999 AAPS Annual Meeting and Exposition, New Orleans, LO, November 1999.

"Quantitative determination of LSD and a major metabolite, 2-oxo-3-hydorxy-LSD, in human urine by solid-phase extraction and gas chromatography tandem mass spectrometry," S.A. Reuschel, S.E. Percey, S. Liu, D.M. Eades, and R.L. Foltz; J Anal Toxicol 1999; 23:306-11.

"Recent advances in chromatographic and mass spectrometric methods for determination of LSD and its metabolites in physiological specimens," S.A. Reuschel, D.M. Eades, and R.L. Foltz; J Chromtogr B 1999; 733:145-59.

"Quantitation of S-59 in human plasma by LC/MS/MS," Donald Eades, Scott Swickard, Rodger Foltz, John Maynard, Jason Hanchett, John Tessman. Tandem Labs and Cerus Corporation. Presented at the 1998 AAPS Annual Meeting and Exposition, San Francisco, CA, November 1998.

"A novel LC/MS/MS method for the determination of stereoisomeric lactones and their corresponding acids," Kerri Trendler, Marc Browning, David Vollmer, Brad Coopersmith, Rodger Foltz, Dara Hawthorn, Mohammed Jemal. Tandem Labs and Bristol-Myers Squibb. Presented at the 1998 AAPS Annual Meeting and Exposition, San Francisco, CA, November 1998.

"Applications of higher-order mass spectrometry," Donald Eades and Rodger Foltz; Presented at the Biomedical Mass Spectrometry Conference: Mass Spectrometry Society of Japan in Isei Shima, Hashikojima, Japan, July 9, 1998.

"Problems and solutions in quantitative determination of drugs and metabolites in physiological specimens by LC-MS/MS," R. Foltz and R. Edom; J Mass Spectrom Soc Jpn 1998; 48:235-40.

"Clinical pharmacokinetics of escalating I.V. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers," M. Brewster, E. Pop, R. Foltz, S. Reuschel, W. Griffith, S. Amselem, A. Biegon. Tandem Labs and Pharmos Corporation. Int J Clin Pharmacol Therapeutics 1997; 35:361-5.

"Quantitative determination of ifetroban and its acylglucuronide metabolite in human plasma by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," B. Coopersmith, K. Mayer, R. Foltz, D. Teitz, M. Jemal.; Tandem Labs and Bristol-Myers Squibb. Presented at the 1996 AAPS Annual Meeting and Exposition, Seattle, WA, October 1996.

"Quantitative determination of BMS-186318 in human plasma and urine by liquid chromatography/tandem mass spectrometry (LC/MS/MS)," C. Nelson, K. Mayer, D. Hawthorne, M. Jemal, R. Foltz. Tandem Labs and Bristol-Myers Squibb. Presented at the 1996 AAPS Annual Meeting and Exposition, Seattle, WA, October 1996.

"GC/MS analysis of body fluids for drugs of abuse," J.T. Cody and R.L. Foltz; In Forensic Applications of Mass Spectrometry, J. Yinon, ed., 1995; Baton Raton: CRC Press, 1-59.

"GC/MS/MS measurement of delta-9-tetrahydrocannabinol, naltrexone, and their active metabolites in plasma," C.C. Nelson, M.D. Fraser, J.K. Wilfahrt, R.L Foltz; Ther Drug Monitoring 1993; 15:557-62.

"Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry," C.C. Nelson and R.L. Foltz; Anal Chem 1992; 64:1578-85.

"Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids," C.C. Nelson and R.L. Foltz; J Chromatography 1992; 580:97-109.